Disruption of TP63-miR-27a* Feedback Loop by Mutant TP53 in Head and Neck Cancer
نویسندگان
چکیده
منابع مشابه
Quality of life in head and neck cancer patients
Quality of life in head and neck cancer patients
متن کاملCoordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells.
The FOXO1 transcription factor orchestrates the regulation of genes involved in the apoptotic response, cell cycle checkpoints, and cellular metabolism. FOXO1 is a putative tumor suppressor, and the expression of this gene is dysregulated in some cancers, including prostate and endometrial cancers. However, the molecular mechanism resulting in aberrant expression of human FOXO1 in cancer cells ...
متن کاملTP53 and head and neck neoplasms.
Head and neck cancer is an important health problem around the world, accounting for approximately 500,000 new cases each year of head and neck squamous cell carcinoma (HNSCC). Carcinogenesis of head and neck results from a dysregulation of cellular proliferation, differentiation, and cell death. The major etiologic agents are tobacco and alcohol consumption and for some cases, human papilloma ...
متن کاملDeficient TP53 expression, function, and cisplatin sensitivity are restored by quinacrine in head and neck cancer.
PURPOSE To determine the nature and potential pharmacologic reversibility of deficient TP53 expression and function in head and neck squamous cell carcinomas (HNSCC) with wild-type TP53, previously associated with decreased sensitivity to cisplatin therapy. EXPERIMENTAL DESIGN TP53 genotype, mRNA and protein expression, TP53-induced p21 expression, and TP53 DNA-binding and reporter gene funct...
متن کاملQuality of life and OHRQoL in head and neck cancer patients in Kerman, Iran
BACKGROUND: Head and neck cancer is one of the six most prevalent neoplasms worldwide. Regardless of tumor site, deterioration of basic functions affecting head and neck areas are perceived and affect patients' lives. The aim of this study was to evaluate quality of life (Short Form) and oral health related quality of life (OHIP-14) in patients with head and neck cancer. METHODS: This study was...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2019
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djz097